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CALGB Celebrates 50th Anniversary


This year marks the 50th anniversary of the Cancer and Leukemia Group B (CALGB), a national clinical trials cooperative group sponsored by the National Cancer Institute and headquartered, since 1995, at the University of Chicago. The CALGB is a network of more than 250 academic medical centers and community hospitals and 3000 oncology specialists that collaborate in enrolling more than 4000 patients annually on approximately 100 active studies. The group was founded when Congress awarded $5 million to NCI to support the study of chemotherapy in treating cancer.

In 1955, a formal inter-institutional protocol comparing continuous to interrupted combination chemotherapy for treatment of acute leukemia began, the first protocol to be undertaken by the Acute Leukemia Group B (ALGB), forerunner of the CALGB, as it was renamed in 1976 to reflect the increasing scope of the research program.

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“The founders of the CALGB were pioneers who forged the discipline of medical oncology, demonstrated that drugs could be used to cure advanced cancer, developed the principles of contemporary multidisciplinary cancer treatment, and recognized that successful cancer treatment must focus on the patient as well as the disease,” says Richard L. Schilsky, M.D., Professor of Medicine and Chairman of the CALGB.

The CALGB is dedicated to improving the lives of cancer patients through the development of improved methods of cancer diagnosis, treatment, and prevention. Recent accomplishments of the CALGB include: the development and FDA approval of new chemotherapy treatments for breast cancer, myelodysplastic syndrome and T cell acute leukemia; the demonstration that older women with early stage breast cancer can safely forego radiation therapy after lumpectomy; the discovery of several new molecular genetic abnormalities in acute leukemia that impact prognosis and may be novel targets for therapy; the demonstration that daily aspirin can significantly reduce the formation of new colon polyps in survivors of colorectal cancer, and the demonstration that hepatic artery infusion of chemotherapy prolongs the survival and improves the quality of life of colon cancer patients compared with conventional treatment.

The CALGB will commemorate fifty years of pioneering cancer research with a gala celebration at the Summer Group meeting this summer.

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